Therapeutic Importance of Biological Half-Life of Antineoplastic Agents- A Review

Lung, prostate, and stomach cancer are the most prevalent cancers among males. Breast, colon, cervical women. The literature also shows that patients suffering from increasing constantly, hence number of different chemotherapy treatments administered is increasing. main objective this review article to summarize effect age on half-life some antineoplastic drugs belonging category Topoisomerase inhibitors, alkylating agents, anthracyclines, purine analogs, antimetabolites, N-nitrosoureas along with their pharmacokinetic properties. Literature indicates highly bound have higher differences in unbound drug concentrations patients, cases, amount concentration not reflective level has an impact parameters, including absorption, volume distribution, metabolism, excretion. Protein binding affects distribution bioavailability active substances.